ANTIBODY PRODUCTS
Applications Key
WB = Western Blot
IP = Immunoprecipitation
IAC= Immunoaffinity Column
ChIP= Chromatin Immunoprecipitation
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Monoclonal Antibodies to botulinum neurotoxin |
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Sample pack of 6 affinity purified monoclonal antibodies botulinum neurotoxin. 25ug of each antibody.
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Catalog #: SP013 -
$150.00
Size:
6 Pack
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| Details: |
| Tested Applications |
ELISA |
| Target Information |
Botulinum neurotoxin type A is a 149.45kDa neurotoxin |
| Product Format |
Affinity Purified |
| Alternate Names |
Botulinum neurotoxin type A, Bontoxilysin-A, BOTOX, botA, bna |
| Clone |
Multiple |
| Host |
Mouse |
| Isotype |
Ig |
| Immunogen |
Recombinant Protein |
| Epitope |
a.a. 870 - 1295 |
| Relevance |
Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure. |
| Specificity |
Botulinum neurotoxin A1 |
| Reported Reactivity |
Unknown |
| Reported Applications |
Unknown |
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Technical Data Sheet  Relevant LinksNCBI YP_001253342Swiss Prot P10854Literature Search  |
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Monoclonal Antibodies to botulinum neurotoxin
